Endocrine Abstracts

Multiple myeloma is a neoplastic disorder arising from plasma cells in the bone marrow. Plasma cell tumors, plasmacytomas, are uncommon in the brain and occur usually in the leptomeninges with or without parencymal involvement. Extramedullary plasmacytomas are very rarely located in the sella and can be misdiagnosed as a nonfunctioning pituitary adenoma. We report an illustrative case with multiple myeloma who was diagnosed having sellar plasmacytoma resembling a nonfunctionin...

Sex reversal syndrome (SRS) is a kind of human genetic disease about gender dysplasia, which is characterised by inconsistency between gonadal sexuality and chromosome sexuality. The clinical types include 46, XY female SRS and 46, XX male SRS. The early studies of human gonadal differentiation found that human Y chromosome contains testis-determining factor (TDF) found that the sex-determining region Y (SRY) gene, which is located in Y chromosome, was the best candidate gene ...

Benign symmetric lipomatosis (BSL) is a very rare disorder characterized by the growth of uncapsulated masses of adipose tissue, predominantly located in the neck and shoulders. Benign symmetric lipomatosis is usually described in adults between 30 and 60 years of age and is slightly more frequent in men with heavy alcohol consumption. A 70-year-old woman presented with a great growth of soft tissues in the cervico-occipital region who had never consumed any alcohol. Laborator...

A 50-year-old man admitted to our institution with labile hypertension. His blood pressure was 150/90 mmHg and the pulse rate was 96 beats per minute. He had hypertensive attacks every 2–3 days. His blood pressure was found 210/110 mmHg at hypertensive attact. He had palpable thyroid nodule. Ultrasonography of the thyroid gland showed a 2.6 cm sized, irregularly marginated, calcified thyroid nodule. His serum free thyroxine (fT4), free triiodothyronine (fT3), thyrotropin ...

Although subclinical Cushing’s syndrome (SCS) is an important metabolic risk factor in patients with adrenal incidentaloma, the diagnostic criteria for SCS has not been established yet. The aim of this study was to evaluate the diagnostic measures of SCS and to investigate the availability of insülin hypoglycemia test (IHT) in the diagnosis of SCS. Twenty patients with adrenal incidentaloma CT characteristics highly suggestive of benign adrenal adenoma with no overt ...

The relationship between increased risk of cardiovascular disease (CVD) and atherosclerosis in subclinical hypothyroidism (sHT) have been demonstrated in several studies. This relation was attributed to dyslipidemia which is common in sHT. Apo A1, apo B100, Lp (a), hsC-reactive protein (hsCRP), fibrinogen and total homocysteinemia (tHcy) are the main non-traditional cardiovascular risk factors. In addition, paraoxon 1 (PON 1) activity is an enzyme responsible for the anti-oxid...

Many causes of levothyroxine malabsorption have been described in the literature such as celiac disease, giardiasis, severe liver cirrhosis and drug interactions. A 27-year-old woman admitted to our institution with overt hypothyroidism symptoms. She had total thyroidectomy for thyroid papiller carcinoma and was using 400 μg/day levothyroxine (LT4). Her serum free thyroxine (fT4), free triiodothyronine (fT3) and thyrotropin stimulating hor...

In new classification of autoimmune polyendocrine syndromes (APS), APS-3 has defined as combination of autoimmune thyroid disease and other autoimmune disease except hypoparathyroidism and Addison’s disease. The present report describes a patient with APS-3 and pseudomalapsorbtion of levothyroxine (LT4). Twenty-three year old woman was referred to our center with hypothyroidism due to Hashimoto’s thyroiditis (HT) despite the usage of high dose LT4 treatment. HT was d...

Background: Clinical practice guidelines on diabetes mellitus (DM) have been developed in 2006 by The Society of Endocrinology and Metabolism of Turkish (SEMT). The ongoing ADMIRE Project is designed to evaluate the effect of implementation of various activities to increase the awareness of physicians on the adherence to SEMT guidelines. The first phase results of the project is presented.Methods: Of 180 physicians evaluated previous 12 months’ medi...

Hyperinsulinemia that occurs due to insulin resistance play an important role on the development of type 2 diabetes and hypertension. It is shown that apart from their angiotensin II receptor blockage effect, telmisartan and irbesartan can activate intracellular hormone receptor PPARγ. Owing to this dual effect, telmisartan and irbesartan can improve cardiovascular risk factors related to insulin resistance. The aim of this study was to compare the effects of telmisartan ...